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June 10, 2022: Ratio Therapeutics Launches to Discover and Drive Early Clinical Development of Best-in-Class Targeted Radiopharmaceuticals for Treatment of Cancers

Company Emerges from Stealth Mode with More Than $20 Million in Seed Financing and Fully Funded Development Alliances with Bayer and Lantheus

BOSTONJune 10, 2022 /PRNewswire/ -- Ratio Therapeutics Inc. today announced its launch with a mission to develop best-in-class targeted radiopharmaceuticals for the treatment of cancers. Founded by entrepreneurial scientists Jack Hoppin, Ph.D., and John Babich, Ph.D., Ratio emerges from stealth mode with more than $20 million in seed funding, fully funded development alliances with Bayer AG and Lantheus Holdings Inc., a robust portfolio of assets developed with two proprietary technologies, and a growing team of world-class experts in radiopharmaceuticals discovery and development. The company's near-term plans call for the submission of its first investigational new drug (IND) applications, which are expected this quarter, and the initiation of clinical trials later this year. Based in Boston, Ratio is set to move to a new 19,000-square-foot headquarters and research facility in the Seaport District in January.  

Ratio's radiopharmaceuticals strategy is focused on optimizing tumor localization while minimizing uptake by normal tissues. To achieve this, the company uses its proprietary technology platform called Trillium™ that is based on Dr. Babich's prior research at Weill-Cornell Medical College and first developed and validated by the founders in a previous venture. Trillium is a trifunctional small molecule scaffold that can be fine-tuned to alter its plasma clearance, target affinity and therapeutic payload. Each component of the scaffolding can be independently optimized to boost tumor uptake over normal tissue uptake, thereby maximizing therapeutic index. Ratio has successfully applied this framework to several tumor targets and multiple therapeutic payloads.

In addition, Ratio is developing a technology platform to take advantage of the tumor killing power of the alpha emitter, Actinium-225. This proprietary technology is called the Macropa™ chelate platform. Ratio's scientists have already successfully incorporated Macropa into the Trillium platform as well as several peptides and antibodies. Macropa's unique chemistry enables ease of manufacture and robust in vitro and in vivo stability of the resulting radiotherapeutic compound.

"The ability to fine-tune our targeted radiotherapeutics using Trillium and Macropa enables us to address head-on the trifecta of typical challenges we see with most radiopharmaceuticals: delivery, safety and efficacy," said Dr. Babich, Ratio's President and Chief Scientific Officer. "Over the past year, we have generated significant preclinical data that demonstrate our ability to create excellent performing drug candidates that now are advancing into the clinic. Our goal is to become the partner of choice for pharmaceutical companies committed to this area of cancer therapy by enabling the optimization of a broad array of targeting compounds. We will shepherd these therapies through early clinical studies on our own or in collaboration."  

Dr. Hoppin, Ratio's Chairman and Chief Executive Officer, added, "Targeted radiotherapy is an exciting and emerging field where chemistry meets physics meets medicine. We have assembled and will continue to build a world-class interdisciplinary team of researchers and developers with a singular focus on delivering these treatments to cancer patients. It isn't often that a start-up company has in place the early financial backing and industry support to advance entirely new drug discoveries to clinical development at this pace. It is with great pride that we announce our formal launch and exit from stealth mode."       

In collaboration with Bayer, Ratio has leveraged its Trillium platform for the identification of lead prostate-specific membrane antigen (PSMA)-targeted therapeutic compounds for prostate cancer. At the same time, Ratio is working with Lantheus to develop a lead fibroblast activation protein (FAP)-targeted PET diagnostic compound for a broad array of epithelial-derived cancers, such as breast, pancreatic, lung and stomach cancer. Both collaborations are fully funded and reflect the types of partnerships that Ratio is currently pursuing with other companies.  

About Ratio Therapeutics

Ratio Therapeutics Inc. is a Boston-based pharmaceutical company with the mission to accelerate the development of next-generation precision radiopharmaceuticals for solid tumors and transform oncology treatment paradigms. Founded by John Babich, Ph.D., and Jack Hoppin, Ph.D., the company currently employs a growing team of radiopharmaceuticals discovery and development experts with backgrounds in the life science industry. Ratio's fully integrated proprietary R&D platforms, Trillium™ and Macropa™, enable the imaging, discovery and advancement of novel radiopharmaceuticals that have first/best-in-class delivery, safety and efficacy properties. The tunable nature of the company's platforms enables the efficient and timely generation of numerous novel radiopharmaceuticals for a broad range of high unmet need in solid tumors. Built to be the radiopharmaceuticals discovery and development partner of choice, Ratio currently collaborates with Bayer and Lantheus.   

Please visit www.ratiotx.com for more information and follow us on Twitter and LinkedIn.

Media Contacts:
Russo Partners, LLC
Erica Fiorini, Ph.D.
Erica.fiorini@russopartnersllc.com
Kathleen Silverman, Ph.D.
Kathleen.silverman@russopartnersllc.com

July 6, 2022: Eckert & Ziegler Becomes Contract Manufacturer for Clinical Development Candidates Based on Lutetium-177 and Actinium-225

Berlin, 6 July 2022. Eckert & Ziegler (ISIN DE0005659700, SDAX) has signed an agreement with the U.S. pharmaceutical company Ratio Therapeutics Inc. for the joint development and manufacture of innovative radiopharmaceutical products based on Lu-177 and Ac-225. The agreement covers the development of a validated manufacturing process as well as the GMP-compliant production of clinical investigational products. Ratio Therapeutics will use the newly built GMP suites at the Eckert & Ziegler production site near Boston, MA, USA, from July 2022 for this purpose.

"The growing interest in radiopharmaceuticals is creating a huge demand for expertise in the development and manufacture of investigational products. Due to the need to reduce costs, the pharmaceutical industry has initiated a paradigm shift in recent years - from a vertically integrated business model to a more cost-efficient supplier network. With our new GMP suites and our many years of know-how, we support the pharmaceutical industry in bringing their radiopharmaceuticals to market more quickly," explains Dr. Lutz Helmke, Executive Director and Chief Operating Officer at Eckert & Ziegler for the Medical segment.

“With Eckert & Ziegler, we have an established partner with best-in-class radiopharmaceutical manufacturing capabilities for medical and scientific use,” commented Dr. Matthias Friebe, Chief Technology Officer at Ratio Therapeutics. “Their expertise in radiopharmaceutical manufacturing will ensure high-quality products and robust manufacturing and logistics expertise for our upcoming clinical programs as we rapidly move toward the submission of our first investigational new drug (IND) application.”

The Eckert & Ziegler radiopharmaceutical production facility in Boston, MA, USA, has state-of-the-art hot cells for alpha, beta and gamma emitters, radiosynthesis, quality control and other equipment for production under GMP conditions. The rentable clean room suites are optimized for carrying out processes for the production of radiopharmaceuticals.

With the GMP facility, Eckert & Ziegler offers both regional and global pharmaceutical companies a one-stop service for a variety of radiopharmaceutical services under GMP and cGMP conditions. These include complete early development services including process development and scale-up, CMC manufacturing and packaging, product release and stability programs. As a radiopharmaceutical contract manufacturer, Eckert & Ziegler is able to produce small batches for Phase I, II and III clinical studies and large commercially applicable batch sizes.

About Eckert & Ziegler.
Eckert & Ziegler Strahlen- und Medizintechnik AG with more than 900 employees is one of the world's largest providers of isotope-related components for nuclear medicine and radiation therapy. The company offers services for radiopharmaceuticals at its worldwide locations, from early development to commercialization. Eckert & Ziegler shares (ISIN DE0005659700) are listed in the SDAX index of Deutsche Börse.
Contributing to saving lives.

About Ratio Therapeutics.
Ratio Therapeutics Inc. is a Boston-based pharmaceutical company with the mission to accelerate the development of next-generation precision radiopharmaceuticals for solid tumors and, thus, transform oncology treatment paradigms. Ratio’s fully integrated proprietary R&D platforms, Trillium™ and Macropa™, enable the imaging, discovery and advancement of novel radiopharmaceuticals that have first/best-in-class delivery, safety and efficacy properties. The tunable nature of the company’s platforms allows the generation in an efficient and timely manner of numerous novel radiopharmaceuticals for a broad range of high unmet need in solid tumors. Please visit www.ratiotx.com for more information and follow us on Twitter and LinkedIn.

Contact:
Eckert & Ziegler AG
Robert-Rössle-Str. 10, 13125 Berlin, Germany
Karolin Riehle, Investor Relations / Jan Schöpflin, Marketing
karolin.riehle@ezag.de / jan.schoepflin@ezag.de
Tel.: +49 (0) 30 / 94 10 84-138; www.ezag.com  

Ratio Therapeutics Media Contact:
Russo Partners, LLC
Erica Fiorini, Ph.D.
Erica.fiorini@russopartnersllc.com  
+1 (914) 310 81-72

September 15, 2022: Ratio Therapeutics Appoints Jacob Hesterman, Ph.D., as Chief Data Officer

BOSTON, September 15, 2022 – Ratio Therapeutics Inc., a pharmaceutical company that employs a suite of innovative technologies to develop best-in-class targeted radiotherapeutics for the treatment of cancers, today announced the appointment of Jacob Hesterman, Ph.D., as the company’s Chief Data Officer (CDO). In this newly created role, Dr. Hesterman will build the company’s data management and data sciences infrastructure. In addition to oversight of the data platform, Hesterman will manage imaging and dosimetry for Ratio’s discovery and clinical programs.

 

“We are delighted to welcome Jacob to the management team and into a new leadership role at Ratio. He brings extensive experience in analytics and software informatics across all stages of drug development and has profound leadership experience in managing and facilitating research and development goals - qualities that align with our fast-growing company’s goals and mission,” commented Dr. Jack Hoppin, Ratio’s Chairman and Chief Executive Officer. “Jacob is the perfect addition to a growing team of researchers and developers with a singular focus on delivering the best treatments to cancer patients.”

 

Dr. Hesterman has 15+ years of experience in medical imaging, data analysis, and the management of interdisciplinary technical teams. Prior to joining Ratio, Dr. Hesterman was a founding member of Invicro, first serving as Senior Vice President of Image Analysis and then as Chief Technology Officer and ultimately as the Chief Technology Officer of Realm IDx, the parent company of Invicro. He built a 60+ person image analysis group at Invicro to provide quantitative analysis for programs across multiple imaging modalities in all phases of drug discovery and development. As CTO of Realm IDx he oversaw more than 150 data scientists focused on integrated diagnostics software and applications.

“I am excited to be a part of Ratio’s team and I look forward to working with my new colleagues to enable the imaging, discovery and advancement of novel radiopharmaceuticals,” said Dr. Hesterman. “I believe the team at Ratio is applying cutting-edge science and technology to the development of their radiotherapeutics and I am delighted to join Ratio’s world-class co-founders, Drs. Hoppin and Babich in their commitment to developing effective treatments for cancer patients.”

 

Dr. Hesterman owns patents for his previous work and has been a member of both the Society of Nuclear Medicine and the World Molecular Imaging Society since 2014. He holds a Ph.D. in Optics from The University of Arizona, USA.

 

About Ratio Therapeutics

Ratio Therapeutics Inc. is a Boston-based pharmaceutical company with the mission to accelerate the development of next-generation precision radiopharmaceuticals for solid tumors and transform oncology treatment paradigms. Founded by John Babich, Ph.D., and Jack Hoppin, Ph.D., the company currently employs a growing team of radiopharmaceuticals discovery and development experts with backgrounds in the life science industry. Ratio’s fully integrated proprietary R&D platforms, Trillium and Macropa, enable the imaging, discovery and advancement of novel radiopharmaceuticals that have first/best-in-class delivery, safety and efficacy properties. The tunable nature of the company’s platforms enables the efficient and timely generation of numerous novel radiopharmaceuticals for a broad range of high unmet need in solid tumors. Built to be the radiopharmaceuticals discovery and development partner of choice, Ratio currently collaborates with Bayer and Lantheus.   

Please visit www.ratiotx.com for more information and follow us on Twitter and LinkedIn.

Media Contacts:

Russo Partners, LLC

Erica Fiorini, Ph.D.

Erica.fiorini@russopartnersllc.com